BDBM50577297 CHEMBL4851439

SMILES FC(F)c1cncc(c1)-c1ccc2ncc3nnc(C4=CCCOCC4)n3c2c1

InChI Key InChIKey=ATKHYZXUMVNCIO-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50577297   

TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50577297(CHEMBL4851439)
Affinity DataIC50:  81nMAssay Description:Inhibition of DNA-PK (unknown origin) using biotin-PEG2-TWSLPLSQDSASE-amide as substrate incubated for 60 mins in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50577297(CHEMBL4851439)
Affinity DataIC50:  69nMAssay Description:Inhibition of DNA-PK in human HT-144 cells assessed as reduction in gammaH2AX phosphorylation incubated for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed